History of consideration of acrylamide listing for reproductive toxicity endpoints: Relevant information related to the possible listing of this chemical was requested in a notice published in the California Regulatory Notice Register on August 22, 1997 (Register 97, No. 34-Z).
Pharmacokinetic data in humans are sparse. 7. NON-CANCER TOXICITY. 7.1.
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The present experiment was conducted to investigate the testicular toxicity of oral acrylamide exposure in male rats and the role of garlic oil in amelioration of this toxicity. 3.1 Acute toxicity. The acute toxicity of acrylamide has been studied in a number of laboratory animals (mouse, rat, guinea pig, rabbit, cat, dog, monkey). LD 50 ‐values for rats range from 120 mg/kg after intraperitoneal injection to 203 mg/kg after oral administration . Terrestrial toxicity . Endpoint summary; Acrylamide EC Number: 201-173-7 EC Name: Acrylamide CAS Number: 79-06-1 Molecular formula: C3H5NO IUPAC Name: prop-2 References Bull, R. J., Robinson, M., Laurie, R. D., Stoner, G. D., Greisiger, E., Meier, J. R., & Stober, J. (1984). Carcinogenic effects of acrylamide in Sencar and Reference substance name: Acrylamide EC Number: 201-173-7 EC Name: Acrylamide Cas Number: 79-06-1 Molecular formula: C3H5NO IUPAC Name: prop-2-enamide The synthesis of poly(N-isopropylacrylamide) began with the synthesis of the acrylamide monomer by Sprecht in 1956.
A Review on Acrylamide in Food: Occurrence, Toxicity, and Mitigation Strategies Lubna Rifai and Fatima A. Saleh International Journal of Toxicology 2020 39 : 2 , 93-102
Acrylamide can form naturally from chemical reactions in certain types of starchy foods, after cooking at high temperatures. Some foods with higher levels of acrylamide include French fries, potato chips, foods made from grains (such as breakfast cereals, cookies, and toast), and coffee. Does acrylamide cause cancer? According to the EFSA, the main toxicity risks of acrylamide are "Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity ".
1998-12-01 · Acrylamide (ACR) is an important industrial chemical used primarily in the production of polymers and co-polymers. Acrylamide is mainly neurotoxic to experimental animals as well as humans and has also been shown to be mutagenic and carcinogenic. The present study was designed to investigate the toxicity of ACR on isolated rat hepatocytes.
The high aquatic toxicity PAM - PE shows in pure water is reduced by several orders Cationic polyacrylamides, polyelectrolytes, polymer, acrylamide, choline. effects of methylmercury, okadaic acid and acrylamide. Additionally, in P19 neurons and differentiated SH-SY5Y cells, we could demonstrate that toxicity of Acrylamide-induced neurotoxicity, reproductive toxicity, genotoxicity, and carcinogenicity are potential human health risks based on animal studies.
2015 — Handelsnamn: Acrylamide (1,2,3-13C3,99%) (+100 ppm STOT SE 1: Specific target organ toxicity - Single exposure, Hazard Category 1. Since 2009 the main goal of his work is toward a paradigm shift in toxicity for her poster titled “The effect of acrylamide on proliferation and differentiation in the
11 apr. 2014 — Acute Inhalation Toxicity - Vapors.
Lex generalis dan lex specialis
Acrylamide has been previously shown to cause several types of cancer in animals, but more information was needed to better understand how acrylamide causes tumors and at what doses the tumors occurred in animals.
was synthesized by grafting poly (N-isopropyl acrylamide) (PNIPAM)
SOU 1998:60. Calleman CJ (1996) The metabolism and pharmacokinetics of acrylamide: Implications for mechanisms of toxicity and human risk. Drug Metab. 10 dec.
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Toxicity and carcinogenicity Europe. According to the EFSA, the main toxicity risks of acrylamide are "Neurotoxicity, adverse effects on male reproduction, developmental toxicity and carcinogenicity". However, according to their research, there is no concern on non-neoplastic effects.
The various types of toxicities caused by Acrylamide and the modulation studies using phytochemicals that are carried out on various type of toxicity like neurotoxicity, hepatotoxicity, cardiotoxicity, immune system, and skeletal system, as well as embryos have been explored. Acute oral exposure to acrylamide has resulted in neurotoxic effects in rats and effects on the kidney in monkeys exposed by injection. (1) Tests involving acute exposure of rats, mice, rabbits, and guinea pigs have demonstrated acrylamide to have highacute toxicity from oral or dermal exposure. (5) 2020-02-04 · Acrylamide (AA) is a food contaminant present in a wide range of frequently consumed foods, which makes human exposure to this toxicant unfortunately unavoidable.